In an unprecedented development, CHOP has joined the PLGA fight! World class researchers, Dr. Thomas Curran (Professor of Cell and Developmental Biology and Professor of Pathology and Laboratory Medicine) and Dr. Adam Resnick (Professor of NeuroSurgery) have taken the lead at CHOP Research Institute to investigate the genomics of Grade II Fibrillary Astrocytomas.

Background: The Childhood Brain Tumor Tissue Consortium (CBTTC) was created with the aim of improving outcomes for children with brain tumors by facilitating research on new prognostic biomarkers and therapies. The mission of the CBTTC is to collect high quality brain tumor specimens, develop cell lines and translatable tumor models from submitted biopsy specimens and share the results obtained from these efforts with CBTTC member institutions* and the world-wide scientific community.

Current: While the CBTTC biorepository, housed at CHOP, encompasses all brain tumor types, with the support from the PLGA Foundation (in partnership with the Why Not Me? Foundation) this study will advance the genetic and molecular characterization of WHO grade II, Diffuse Fibrillary Astrocytomas. This is a targeted PLGA research study that will not only inform about one type of PLGA tumor, but many others as well.

This project accomplishes goals, which will impact the scientific understanding about these tumor types, but it also creates a full academic collaboration uniting numbers of centers of medical excellence in the world. Not only will the study results be shared with the participating CBTTC consortium members, they will also be shared by the PLGA Research Program at the Dana Farber Cancer Institute and the Boston and Beijing Genome Institute, China.

The PLGA Foundation (in partnership with the Why Not Me? Foundation) envisions that this will be the first of many projects which involve the collaborative efforts of CHOP and CBTTC in pushing the PLGA research agenda forward to find more effective treatments and a cure for children battling all forms of PLGA.

*CBTTC member institutions include CHOP, Children’s Hospital of Pittsburg, Seattle Children’s Hospital and Children’s Memorial Hospital, Chicago. Initial funding for creating the biorepository infrastructure was generously supported by the Children’s Brain Tumor Foundation.