UCSF, reports that discoveries from projects funded by the PLGA Foundation have formed the basis for extended research and treatment of BRAF V600E pediatric brain tumors within the context of the UCSF Brain Tumor SPORE. This is the first time in which a project specific to pediatric brain tumor research and therapy has been a part of a Brain Tumor SPORE grant. The Translational Research Program at the National Cancer Institute is the home to the Specialized Program Of Research Excellence (SPORE). There are currently only 4 institutions in the country with active Brain Tumor SPORE grants. All grants are required to promote collaborative, interdisciplinary translational cancer research. SPORE grants involve both basic and clinical/applied scientists and support projects that will result in new and diverse approaches to the prevention, early detection, diagnosis and treatment of human cancers. The objective for all SPOREs is to reduce cancer incidence and mortality, and to improve survival and quality of life for cancer patients. The pediatric LGA component of the UCSF Brain Tumor SPORE initiative entitled “Novel Approaches for Improving Pediatric BRAFV600E Glioma Patient Outcomes” represents a five-year effort with over $1,000,000 in direct costs support.

In addition to the SPORE funding, since the period of support, UCSF PLGA investigators Rowitch/James have been successful in obtaining $1.5M additional funding for the following projects:

Institution Study Name Principle Investigator Grantor Duration
University of California, San Francisco (UCSF) BRAF-driven pediatric malignant astrocytoma: etiology & treatment Rowitch/James (Co-PIs) James McDonnell Foundation 2010-2013
University of California, San Francisco (UCSF) BRAF-Neural Precursor Interactions in Pediatric Malignant Gliomagenesis Griveau / Rowitch (Fellow / Mentor) American Brain Tumor Association Basic Research Fellowship 2010-2012
University of California, San Francisco (UCSF) Phosphorylated-Olig2 Biochemical Function in Pediatric Glioma Griveau / Rowitch (Fellow / Mentor) AACR Anna D. Barker Fellowship in Basic Cancer Research 2012-2013
University of California, San Francisco (UCSF) Pediatric glioma: cellular origins and oncogenic signaling Tien / Rowitch (Fellow / Mentor) American Brain Tumor Association Basic Research Fellowship 2012-2014