In this A Kids’ Brain Tumor Cure (PLGA Foundation) funded project, Dr. Denise Sheer and colleagues show that microRNAs that regulate critical signalling pathways in pilocytic astrocytomas are more abundant in these tumours than in diffuse astrocytomas. This is interesting because these signalling pathways drive the balance between cell division and the senescence state where cells stop dividing, and this realization helps improve our understanding of the different elements that control the pathways. These findings provide further evidence of a senescent phenotype in pilocytic astrocytomas. In addition they suggest that the ERK/MAPK pathway, which is considered the major driver of these tumours, is regulated not only by genetic aberrations but also by microRNAs. The complete manuscript of this study can be found here.