Monthly Archives: October 2008

Peptide Vaccine Based Immunotherapy for Pediatric Low-Grade Glioma

October 23rd, 2008|

Principal Investigator: Ian Pollack, MD, Childrens Hospital of Pittsburgh, Pittsburgh, Pennsylvania

The prognosis for children with treatment-refactory low-grade gliomas is suboptimal, and new treatment approaches are needed that target the […]

Identification of the Molecular Signature of Progressive JPA

October 23rd, 2008|

Principal Investigator: Elizabeth Maher, MD, PhD, University of Texas Southwestern Medical Center, Dallas, Texas

Pilocytic astrocytomas (PA), the most common childhood brain tumor, is classified into 2 groups, those that […]

Xenograft Mouse Models of Childhood Low-Grade Glioma

October 23rd, 2008|

Principal Investigator: Xiao-Nan Li, MD, PhD, Texas Children’s Hospital-Baylor College of Medicine,
Houston, Texas

The goal of this project is to develop and characterize a panel of primary tumor-based orthotopic xenograft […]

A Phase II Study of RAD001 for Children with Chemotherapy Hemotherapy

October 23rd, 2008|

Principal Investigator: Mark Kieran, MD, PhD, Dana-Farber Cancer Institute, Boston, Massachusetts

Low-grade gliomas are the most common brain tumor in children. While a portion of patients are effectively cured with […]

Targeting the Hedgehog Pathway in Pediatric Low-Grade Glioma

October 23rd, 2008|

Principal Investigator: Michael K. Cooper, MD, Vanderbilt University Medical Center, Nashville, Tennessee

The intractable nature of gliomas to current chemotherapies and radiation underscores a tremendous need for improved interventions. A […]