Principal Investigator Dr. David H. Rowitch, Dr. C. David James, Dr. Graeme Hodgson, Ph.D. University of California, San Francisco
The ultimate goal of this proposal is to change the landscape of pediatric grade II glioma (fibrillary astrocytoma) research by investigating the biological regulation of cancer stem cells. The three specific aims of this program are as follows:
Investigate the function of OLIG2-positive stem cells in pediatric low-grade glioma
Develop novel mouse orthotopic models of low-grade glioma.
Identity genes that cause diffuse low-grade astrocytomas (DLGAs), and to test the efficacy of small inhibitory nucleic acids (siNA) that target these genes in preclinical models of DLGAs.