At the July 2nd, 2008 International Society of Pediatric Neuro-Oncologists meeting in Chicago, more than 100 families with children suffering from brain tumors gathered to ask questions directed at an interdisciplinary panel of pediatric brain tumor physicians. In this short video, Dr. Kieran shares a concise definition of the way a clinical trial protocol is structured and Dr. Goldman defines the three different Phases that a clinical trial can be registered.