ryan

About Ryan S.

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So far Ryan S. has created 8 entries.

A Phase I Study of PLX8394 Plus Ritonavir in Children with Recurrent or Progressive BRAF Activated Gliomas

June 13th, 2018|

A Phase I Study of PLX8394 Plus Ritonavir in Children with Recurrent or Progressive BRAF Activated Gliomas

Principal Institutions: Children’s Hospital of Los Angeles in partnership with the Pediatric Brain […]

A Phase I/II and Target Validation Study of TAK-580 (MLN2480) for Children with Low-Grade Gliomas and Other RAS/RAF/MEK/ERK Pathway Activated Tumors

May 13th, 2018|

Principal Institutions: Dana Farber Cancer Institute in partnership with the Pacific Pediatric Neuro Oncology Consortium (PNOC).  Oncogenic dysregulation of the RAS/RAF/MEK/ERK pathway has been described in a number of diverse malignancies, […]

Critical Mechanisms of Gene Regulation in Medulloblastoma

May 13th, 2018|

Under the leadership of Dr. Miguel Rivera at Massachusetts General Hospital, this project focuses on medulloblastoma. Medulloblastoma is the most common malignant brain cancer in children and consists of […]

Phase 1 study of APX-005M CD40 agonist antibody in children and young adults with CNS tumors

January 13th, 2018|

Principal Institutions: Memorial Sloan Kettering Cancer Center and Pediatric Brain Tumor Consortium (PBTC) – This early phase, multicenter, open-label study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity, […]

December 2017: PLGA Consensus Symposium, Toronto, Canada

December 17th, 2017|

SickKids of Toronto, Dr. Uri Tabori: – Novel universal classification of childhood low grade gliomas using clinico-pathological and molecular methods.

March 13th, 2017|

Novel universal classification of childhood low grade gliomas using clinico-pathological and molecular methods

The recent progress in both molecular understanding and the exciting preliminary results of targeted therapies […]

Johns Hopkins Medical Center – Dr. Eric Raabe, Dr. Charles Eberhart, Dr. Fausto Rodriguez: Using Human Neural Stem Cells to Create Genetically Accurate Models of PLGG, Developing PLGG Models Using Patient-Derived Tumor Tissue, Dual mTOR/NOTCH inhibition as a Therapeutic Strategy for PLGG

June 13th, 2016|

Using Human Neural Stem Cells to Create Genetically Accurate Models of PLGG, Developing PLGG Models Using Patient-Derived Tumor Tissue, Dual mTOR/NOTCH inhibition as a Therapeutic Strategy for PLGG

This award […]

Phase I Immunotherapy Study of Nivolumab mono therapy and in combination with ipillmumab

May 13th, 2016|

Principal Institution: Memorial Sloan Kettering Cancer Center – This Phase 1 clinical trial tests the safety and efficacy of combination checkpoint inhibitors in the treatment of children with brain […]