Research

ChIP/Seq Core

March 18th, 2012|

Much excitement in the low-grade astrocytoma field has been generated by the discovery of frequent mutations in a protein kinase known as BRAF. However these BRAF mutations can account […]

Development of Clinically Relevant Orthotopic Xenograft Mouse Models of Childhood Low-Grade Glioma from Primary Tumor Tissues

March 18th, 2012|

Principal Investigator: Xiao-Nan Li, MD, PhD, Texas Children’s Hospital-Baylor College of Medicine,
Houston, Texas

The goal of this project is to develop and characterize a panel of primary tumor-based orthotopic xenograft […]

Development of Permanent Juvenile Pilocytic Astrocytoma Cell Lines for Preclinical Trails

March 18th, 2012|

Principal Investigator Dr. Kwong-Kwok Wong, University of Texas M.D. Anderson Cancer Center.
This study will investigate different methods to immortalize JPA primary cells which have limited growth potential. Cell culture […]

Identification of Key Genetic and Growth Control Pathway Changes in JPA that Represent Potential Molecular Targets for…

March 18th, 2012|

Principal Investigators Dr. David Gutmann and Dr. Tobey MacDonald, Washington University
A collaborative project conducting the first truly comprehensive genomic, genetic and proteomic analysis of JPAs. The project is being […]

Identification of the Molecular Signature of Progressive JPA

March 18th, 2012|

Principal Investigator: Elizabeth Maher, MD, PhD, University of Texas Southwestern Medical Center, Dallas, Texas

Pilocytic astrocytomas (PA), the most common childhood brain tumor, is classified into 2 groups, those that […]

NEW Sorafenib clinical trial OPEN for enrollment

May 19th, 2011|

Dr. Matthias Karajannis, New York University’s, Lagone Medical Center just announced that enrollment for the Phase II Study of Sorafenib in Children (and young adults) with recurrent or progressive […]

Conference: Low Grade Glioma – Meta Analysis Symposium

July 18th, 2009|

Following on the heels of the Nottingham, England LGG Conference in July 2009, a strong recommendation was made to try to merge the various low grade glioma databases in […]

Dana Farber Cancer Institute’s Pediatric Low-Grade Astrocytoma Program

May 18th, 2007|

In May 2007, the Dana Farber Cancer Institute kicked off the┬áPediatric Low Grade Astrocytoma Research Program, funded by an initial $2 million grant from 5 families affiliated with the […]

Dana Farber Cancer Institute Projects

May 7th, 2007|

In May 2007, the establishment of the first dedicated PLGA research program at the Dana Farber Cancer Institute. The initial $2 million grant will concentrate resources on research on […]

2006 JPA Statistical Data

January 23rd, 2006|

The Central Brain Tumor Registry of the United States is a not-for-profit corporation which gathers and disseminates epidemiologic data on primary brain tumors in order to facilitate research and […]